Interleukin-4 and interleukin-13 cause barrier dysfunction in human airway epithelial cells
نویسندگان
چکیده
منابع مشابه
Interleukin-4 and interleukin-13 cause barrier dysfunction in human airway epithelial cells
Emerging evidence indicates that airway epithelial barrier function is compromised in asthma, a disease characterized by Th2-skewed immune response against inhaled allergens, but the mechanisms involved are not well understood. The purpose of this study was to investigate the effects of Th2-type cytokines on airway epithelial barrier function. 16HBE14o- human bronchial epithelial cells monolaye...
متن کاملWrestlers’ immune cells produce higher interleukin-6 and lower interleukin-12 and interleukin-13 in response toin vitro mitogen activation
Objective(s):Although recent investigations have shown chronic inflammation and inflammation-associated diseases might be ameliorated by exercise; little is known about the relation between exercise training with anti/pro-inflammatory cytokines. Materials and Methods: This cross sectional study was conducted to compare interleukin-4 (IL-4), IL-6, IL-10, IL-12, IL-13, interferon gamma (IFN-γ) le...
متن کاملInterleukin-4 and interleukin-13 act on glomerular visceral epithelial cells.
In minimal change nephrosis (MCN), proteinuria is associated with structural changes of the glomerular visceral epithelial cells (GVEC). The occurrence of MCN has been associated with 2 lymphocyte-dependent conditions. To examine a direct role for type 2 cytokines in GVEC injury, the expression of interleukin (IL)-4/IL-13 receptors by GVEC and direct effects of IL-4 and IL-13 on GVEC were studi...
متن کاملInterleukin-13 alters mucociliary differentiation of human nasal epithelial cells.
and IL-13, and the T-helper type 1 cytokine interferon (IFN)act differently in regulating airway inflammation and subepithelial fibrosis. The production of transforming growth factor (TGF)by airway epithelium and lung mesenchymal cells may be an important event in airway inflammation and remodeling. We hypothesized, therefore, that Th2 and T-helper type 1 cytokines may differentially regulate T...
متن کاملRegulation of interleukin-1beta and interleukin-1beta inhibitor release by human airway epithelial cells.
In asthma, human airway epithelial cells (HAECs) regulate the intensity of mucosal inflammation, in part, by releasing the pro-inflammatory cytokine interleukin (IL)-1beta. However, the IL-1beta inhibitors, IL-1 receptor antagonist (IL-1RA) and soluble IL-1 receptor type II (sIL-1RII), regulate IL-1beta bioactivity. In order to better understand the control of IL-1beta activity in the airway mu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Tissue Barriers
سال: 2013
ISSN: 2168-8370
DOI: 10.4161/tisb.24333